Regional Precuneus Cortical Hyperexcitability in Alzheimer's Disease Patients.

Elias P Casula,Ilaria Borghi,Michele Maiella,Maria C Pellicciari,Sonia Bonnì,Lucia Mencarelli,Martina Assogna,Alessia D'Acunto,Francesco Di Lorenzo,Danny A Spampinato,Emiliano Santarnecchi,Alessandro Martorana,Giacomo Koch

Annals of neurology（2023）

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摘要

Our data provide novel evidence that precuneus cortical hyperexcitability is a key feature of synaptic dysfunction in patients with AD. The current results point to the combined approach of TMS and EEG as a novel promising technique to measure hyperexcitability in patients with AD. This index could represent a useful biomarker to stage disease severity and evaluate response to novel therapies. ANN NEUROL 2023;93:371-383.

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alzheimer

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