Design, synthesis and biological evaluation of pteridine-7(8H)-one derivatives as potent and selective CDK4/6 inhibitors
Bioorganic & Medicinal Chemistry Letters（2022）
Abstract
•Pteridine-7(8H)-one derivatives were designed through scaffold hopping strategy as CDK inhibitors.•The newly-synthesized derivatives exhibited effective CDK4/6 inhibition activities.•Compound L2 showed excellent selectivity to CDK1/2/7/9.•Compound L2 displayed potent antiproliferative activities in breast and colon cancer cells.
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Key words
CDK4/6 inhibitors,Structure-activity relationships,Scaffold hopping
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