Enantioselective Synthesis of Functionalized Tetrahydropyridines through Iridium-Catalyzed Formal [5+1] Annulation
Organic Letters(2022)
摘要
An efficient iridium-catalyzed asymmetric formal [5+1] annulation by in situ generation of enamines as N- nucleophiles for the synthesis of tetrahydropyridine derivatives is disclosed. The methodology offers direct access to a wide variety of chiral tetrahydropyridine derivatives in moderate to good yields and excellent enantioselectivity.
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关键词
functionalized tetrahydropyridines,enantioselective,synthesis,iridium-catalyzed
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