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Neoadjuvant Chemotherapy Is Associated with Altered Immune Cell Infiltration and an Anti-Tumorigenic Microenvironment in Resected Pancreatic Cancer.

Andressa Dias Costa,Sara A Väyrynen,Akhil Chawla,Jinming Zhang,Juha P Väyrynen,Mai Chan Lau,Hannah L Williams,Chen Yuan,Vicente Morales-Oyarvide,Dalia Elganainy,Harshabad Singh,James M Cleary,Kimberly Perez,Kimmie Ng,William Freed-Pastor,Joseph D Mancias,Stephanie K Dougan,Jiping Wang,Douglas A Rubinson,Richard F Dunne,Margaret M Kozak,Lauren Brais,Emma Reilly,Thomas Clancy,David C Linehan,Daniel T Chang,Aram F Hezel,Albert C Koong, Andrew J Aguirre,Brian M Wolpin,Jonathan A Nowak

Clinical cancer research : an official journal of the American Association for Cancer Research（2022）

Cited 11|Views53
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Abstract
Neoadjuvant chemotherapy with FOLFIRINOX shifts the PDAC immune microenvironment toward an anti-tumorigenic state associated with improved patient survival.
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Key words
chemotherapy,altered immune cell infiltration,cancer,anti-tumorigenic
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