Relationship of serum beta-synuclein with blood biomarkers and brain atrophy.
Alzheimer's & dementia : the journal of the Alzheimer's Association(2023)
摘要
Blood beta-synuclein is increased in Alzheimer's disease (AD) but not in frontotemporal lobar degeneration (FTLD) syndromes. Blood beta-synuclein correlates with temporal brain atrophy in AD. Blood beta-synuclein correlates with cognitive impairment in AD. The pattern of blood beta-synuclein changes in the investigated diseases is different to phosphorylated tau 181 (p-tau181) and neurofilament light (NfL).
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关键词
Alzheimer's disease,FTLD,NfL,beta-synuclein,blood biomarker,brain atrophy,dementia,frontotemporal lobar degeneration,p-tau181,synaptic degeneration
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