Aging Impairs Adaptive Unfolded Protein Response and Drives Beta Cell Dedifferentiation in Humans.
The Journal of clinical endocrinology and metabolism（2022）
Abstract
Our finding highlights that the failure to establish proper adaptive UPR in senescent human beta cells shifts their differentiated states, possibly representing a crucial step in the pathogenesis of age-related beta cell failure.
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Key words
ageing,beta cell dedifferentiation,type 2 diabetes,unfolded protein response
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