Shc Is Implicated in Calreticulin-Mediated Sterile Inflammation in Alcoholic Hepatitis

Yuan Li,Joy X Jiang,Weiguo Fan,Sarah R Fish,Suvarthi Das,Parul Gupta,Gergely Mozes,Lorand Vancza,Sutapa Sarkar,Koshi Kunimoto,Dongning Chen,Hyesuk Park,Dahn Clemens,Alexey Tomilov,Gino Cortopassi,Natalie J Török

Cellular and Molecular Gastroenterology and Hepatology（2023）

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摘要

Alcohol induces p46Shc-dependent activation of pre-apoptotic pathways and translocation of CRT to the membrane, where it acts as a damage-associated molecular pattern, instigating immunogenicity. Shc inhibition could be a novel treatment strategy in AH.

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关键词

Alcoholic Hepatitis,Shc,Calreticulin,Lipid Peroxidation,Sterile Inflammation

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