Poster: IBCL-222 Parallel Testing of Liquid Biopsy (ctDNA) and Tissue Biopsy Samples Yields Higher Frequency of EZH2 Mutations in Follicular Lymphoma

Clinical Lymphoma Myeloma and Leukemia(2022)

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摘要
Here, we have developed a novel, minimally invasive EZH2 mutation detection test. Due to the ability of this approach to resolve spatial heterogeneity, our method detected a higher frequency of EZH2 mutations in FL patients compared to historical data, which further expands the subset of FL patients who would most likely benefit from the recently developed EZH2 inhibitor therapy.
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关键词
IBCL,follicular lymphoma,circulating tumor DNA,liquid biopsy,EZH2,droplet digital PCR
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