Poster: CML-047 Post Hoc Analysis of Responses to Ponatinib in Patients With Chronic-Phase Chronic Myeloid Leukemia (CP-CML) by Baseline BCR::ABL1 Level and Baseline Mutation Status in the OPTIC Trial
Clinical Lymphoma Myeloma and Leukemia(2022)
摘要
The OPTIC post hoc analysis showed clinical benefit across dosing regimens regardless of T315I mutation status at baseline; the 45-mg cohort showed the highest response rates regardless of baseline BCR::ABL1 levels. Regardless of T315I mutation status, most patients were able to maintain their response after dose reduction upon achieving BCR::ABL1 ≤1%. This abstract is an encore from the American Society of Hematology 2021 Annual Meeting.
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关键词
CML,leukemia,ponatinib,TKI,T315I
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