Modern Solutions for Ancient Pathogens: Direct Pathogen Sequencing for Diagnosis of Lepromatous Leprosy and Cerebral Coenurosis

Bernadette C Young,Stephen J Bush,Sam Lipworth,Sophie George,Kate E Dingle,Nick Sanderson,Alice Brankin,Timothy Walker,Srilakshmi Sharma, James Leong,Puneet Plaha,Monika Hofer,Peter Chiodini, B Gottstein,Lavinia Furrer,Derrick Crook,Andrew Brent

OPEN FORUM INFECTIOUS DISEASES（2022）

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摘要

Microbes unculturable in vitro remain diagnostically challenging, dependent historically on clinical findings, histology, or targeted molecular detection. We applied whole-genome sequencing directly from tissue to diagnose infections with mycobacteria (leprosy) and parasites (coenurosis). Direct pathogen DNA sequencing provides flexible solutions to diagnosis of difficult pathogens in diverse contexts.

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关键词

leprosy, coenurosis, Taenia, mycobacteria, whole genome sequencing

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