The association of antiviral drugs with COVID-19 morbidity: The retrospective analysis of a nationwide COVID-19 cohort.

Cenk Babayigit,Nurdan Kokturk,Seval Kul,Pelin Duru Cetinkaya,Sibel Atis Nayci,Serap Argun Baris,Oguz Karcioglu,Pinar Aysert,Ilim Irmak,Aycan Akbas Yuksel,Yonca Sekibag,Oya Baydar Toprak,Emel Azak,Sait Mulamahmutoglu,Caglar Cuhadaroglu,Aslihan Demirel,Bugra Kerget,Burcu Baran Ketencioglu,Hasan Selcuk Ozger,Gulcihan Ozkan,Zeynep Ture,Begum Ergan,Vildan Avkan Oguz,Oguz Kilinc,Merve Ercelik,Tansu Ulukavak Ciftci,Ozlem Alici,Esra Nurlu Temel,Ozlem Ataoglu,Asena Aydin,Dilek Cetiner Bahcetepe,Yusuf Taha Gullu,Fusun Fakili,Figen Deveci,Neslihan Kose,Muge Meltem Tor,Gulsah Gunluoglu,Sedat Altin,Teyfik Turgut,Tibel Tuna,Onder Ozturk,Oner Dikensoy,Pinar Yildiz Gulhan,Ilknur Basyigit,Hasim Boyaci,Ipek Kivilcim Oguzulgen,Sermin Borekci,Bilun Gemicioglu,Firat Bayraktar,Osman Elbek,Ismail Hanta,Hacer Kuzu Okur,Gulseren Sagcan,Oguz Uzun,Metin Akgun,Goksel Altinisik,Berna Dursun,Ebru Cakir Edis,Erkmen Gulhan,Fusun Oner Eyuboglu,Okkes Gultekin,Yavuz Havlucu,Metin Ozkan,Aysin Sakar Coskun,Abdullah Sayiner,A Fuat Kalyoncu,Oya Itil,Hasan Bayram

Frontiers in medicine（2022）

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摘要

Our findings demonstrated that antiviral drugs including lopinavir, ritonavir, and favipiravir were associated with negative clinical outcomes such as increased risks for lengthy hospital stay, ICU admission, and invasive mechanical ventilation requirement. Therefore, repurposing such agents without proven clinical evidence might not be the best approach for COVID-19 treatment.

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关键词

COVID-19 morbidity,ICU requirement,antiviral agents,invasive mechanical ventilation,length of hospitalization

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