Circulating tumor DNA monitoring for early recurrence detection in epithelial ovarian cancer

•Post-surgical ctDNA detection is prognostic of reduced recurrence-free survival.•Post-surgically, ctDNA detected relapse with 100% sensitivity and specificity.•ctDNA detection preceded radiological findings by an average lead time of 10 months.•The presence of ctDNA and not CA-125 was a strong predictor of relapse.