Upregulation of TRPC6 inhibits astrocyte activation and proliferation after spinal cord injury in rats by suppressing AQP4 expression

Jiajun Cai,Jundong Kong,Song Ma, Yaozu Ban,Jian Li,Zhongkai Fan

Brain Research Bulletin（2022）

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摘要

•HYP9 (TRPC6-specific agonist) inhibits astrocyte activation and proliferation in SCI.•TGN-020 (AQP4-specific inhibitor) inhibits astrocyte activation and proliferation in SCI.•HYP9 inhibits AQP4 expression in SCI.•HYP9 or TGN-020 promote neuronal survival in the spinal cord and facilitate recovery of hindlimb motor function in rats after SCI.

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关键词

SCI,TRPC6,BBB,AQP4,GFAP,PCNA,DMSO,PVDF,DAPI,CCK8,IR,DMEM,PBS,NMDAR,MCAO,TRPV4,PMSF,BCA,HRP,TBST,ECL,TUNEL,OGD/R,CREB

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