CtDNA-guided rechallenge with anti-EGFR therapy in RASwt metastatic colorectal cancer: Evidence from clinical practice.

Raffaella D'Onofrio,Francesco Caputo, Francesco Prampolini,Andrea Spallanzani,Fabio Gelsomino,Stefania Bettelli,Samantha Manfredini,Luca Reggiani Bonetti,Pietro Carotenuto,Alessandro Bocconi,Massimo Dominici,Gabriele Luppi,Massimiliano Salati

Tumori（2022）

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摘要

Blood-based RASwt status may enrich metastatic colorectal cancer more likely to benefit from anti-EGFR-based rechallenge. RAS genotyping in ctDNA represents a feasible, fast, and cost-effective tool to be implemented in the clinic for advancing precision medicine.

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关键词

Colorectal cancer,RAS status,anti-EGFR,circulating tumor DNA,liquid biopsy,precision medicine,rechallenge

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