Automatic quantification analysis of amrubicin and amrubicinol using LC-MS/MS

Makoto Maeda,Daisuke Amenomiya,Reiko Ando Makihara,Naomi Sakiyama,Yoshinori Makino,Eishi Imoto,Daisuke Kawakami,Ken Masuda,Yuki Shinno,Yusuke Okuma,Tatsuya Yoshida,Yasushi Goto,Hidehito Horinouchi,Mitsunobu Ishikawa,Yoshimasa Saito, Toru Akagi,Hironobu Hashimoto,Noboru Yamamoto,Yuichiro Ohe,Tetsuya Furukawa

ANNALS OF ONCOLOGY（2022）

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Abstract

Amrubicin (AMR) is an active drug in patients with relapsed or refractory small cell lung cancer. Severe neutropenia is often observed, and in some patients, subsequent treatment delay and/or dose reduction is often required. We clarified the relationship between the absolute neutrophil count-time profiles and the pharmacokinetic properties of AMR and its active metabolite amrubicinol (AMR-OH) previously, and a therapeutic drug monitoring (TDM) study is ongoing. We have developed and validated a fully-automated analytical method for the measurement of AMR and AMR-OH concentrations in human plasma using LC-MS/MS which can be applied simply to TDM.

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Key words

amrubicinol,automatic quantification analysis

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