Semaglutide treatment attenuates vessel remodelling in ApoE−/− mice following vascular injury and blood flow perturbation

Ditte Marie Jensen,Gry Freja Skovsted,Mathilde Frederikke Bjorn Bonde,Jacob Fog Bentzon,Bidda Rolin,Gregory Franck,Maria Katarina Elm Ougaard,Louise Marie Voetmann,Julian Christoffer Bachmann,Anna Uryga,Charles Pyke,Rikke Kaae Kirk,Henning Hvid,Lotte Bjerre Knudsen,Jens Lykkesfeldt,Michael Nyberg

Atherosclerosis Plus（2022）

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摘要

•We assessed the pharmacological effects of semaglutide in atheroprone mice.•The model recapitulates central mechanisms related to VSMC phenotypic switching.•Semaglutide treatment reduced VSMC proliferation and vessel remodelling.•This effect was independent of GLP-1 receptor-mediated signalling in vascular cells.•Such mechanism of action may be important for the cardiovascular protection.

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关键词

Atherosclerosis,Glucagon-like peptide 1 receptor agonists,Semaglutide,Vascular smooth muscle cells,Vascular injury,Phenotypic switching,Plaque erosion

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