Novel loss-of-function mutations in TNFAIP3 gene in patients with lupus nephritis.

Changming Zhang, Xu Han,Li Sun,Sirui Yang,Jiahui Peng,Yinghua Chen,Ying Jin,Feng Xu,Zhihong Liu,Qing Zhou

CLINICAL KIDNEY JOURNAL（2022）

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摘要

Kidney involvement may be the main feature of the clinical spectrum of HA20, even in adults. Genetic screening should be considered for early-onset LN patients.

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关键词

activation of NF-κB and type I IFN pathways,haploinsufficiency of A20,lupus nephritis,novel TNFAIP3 mutations

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