Further and new target-based benzimidazole anthelmintics active against Teladorsagia circumcincta

Journal of Molecular Structure(2022)

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摘要
•Docking studies on modelled tubulin of Teladorsagia circumcincta guided the design, synthesis and study of four types of benzimidazoles (BZs).•55 BZs were assayed on eggs and larvae.•9 BZs displayed ovicidal activity higher than 90% at 50 µM.•6 BZs attained EC50 values in the low  µM range with high (17 to 111) selectivity indexes.•3 BZs submitted to in vivo assays.
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关键词
Benzimidazole derivatives,Teladorsagia,Anthelmintic,Docking,Structure-activity relationships
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