Vaccines: New challenges, new paradigms, new opportunities: Report of the 22nd DCVMN Annual General Meeting

•Partnerships and collaborations key to mitigate the effects of the COVID-19 pandemic and to prepare for future pandemics.•The inequitable access to COVID-19 vaccines is a failure of humanity and will continue to have significant economic and health consequences if not addressed.•Deliberate actions are required to establish sustainable vaccine manufacturing on the African continent.•Innovative vaccine technologies, regulatory and financing mechanisms are critical to strengthening global health security.