Deep learning for automatic diagnosis and morphologic characterisation of malignant biliary strictures using digital cholangioscopy: a pilot study

Conclusion:Augmenting whole liver scRNA seq with spatial transcriptome analysis, is a novel approach to identify cell populations and pathways specific to the damaged peribiliary area.Using this approach we demonstrated that CCL24 regulates cholestatic, inflammatory and fibrotic liver damage, and its underling mechanisms.Understanding the underling mechanisms of CCL24 blockade and its ability to prevent liver injury in animal supports its role in PSC and its potential beneficial effect for PSC patients.