Reduced triglycerides and LDL cholesterol from once-weekly administration of the well-tolerated novel FGF21 analogue 0499

Kirsten Dahl,Jakob Schioler Hansen,Jesper Clausen,Mads Sundby Palle,Cassandra Key,Birgitte Andersen

JOURNAL OF HEPATOLOGY（2022）

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摘要

Conclusion:The novel FGF21 analogue was well tolerated at doses up to 60 mg/week for 12 weeks.Treatment was associated with beneficial effects on lipid profile including lowering of TG and LDL levels.These results are encouraging for the further development of 0499 for treatment of NASH.

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关键词

novel fgf21 analogue,triglycerides,ldl cholesterol,once-weekly,well-tolerated

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