EE214 Impact of Depression Relapse on Participant Quality of Life and Costs to the English NHS: Secondary Analysis from the Antler Study on Antidepressant Discontinuation in Well Patients in Primary Care

Depression is a common and debilitating mental-health condition. Antidepressants are recommended as first-line treatment, often taken for months or years after a depressive episode. The ANTLER study investigated the impact of tapered discontinuation of medication in well patients, compared to maintenance treatment, to determine whether maintenance treatment prevented relapse. The objective was to calculate the impact on health-related quality-of-life (HRQoL) and English National Health Service (NHS) costs of experiencing a depression relapse, using ANTLER patient-level trial data.