Assessing a sustainable manufacturing route to lapatinib

Roderick T. Stark, Dominic R. Pye,Wenyi Chen,Oliver J. Newton,Benjamin J. Deadman,Philip W. Miller,Jenny-Lee Panayides,Darren L. Riley,Klaus Hellgardt,King Kuok (Mimi) Hii

REACTION CHEMISTRY & ENGINEERING（2022）

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摘要

A synthetic route to an anti-cancer drug, lapatinib, was devised to support the development of a sustainable manufacturing process in South Africa. Quantitative metrics were employed to evaluate the sustainability of the key steps of the reaction.

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