Oxo-Carotenoids as Efficient Superoxide Radical Scavengers
ANTIOXIDANTS(2022)
摘要
Oxo-carotenoids containing conjugated carbonyl groups in their chains were designed to be more efficient superoxide radical scavengers than natural carotenoids, beta-carotene and canthaxanthin. A practical chain-extension method for polyene dials (e.g., crocetin dial) was also proposed based on Horner-Wadsworth-Emmons olefination. Double aldol condensation between polyene dials and acetophenones with ring substituents produced oxo-carotenoids with substituted benzene rings. The antioxidant activity of oxo-carotenoids was measured using DPPH (radical) and ABTS (cationic radical) scavenging assays and compared with the analysis with the superoxide (anionic radical) probe. An effective conjugation length by carbon-carbon double bonds is important to provide superior antioxidant activity for oxo-carotenoids, regardless of the type of radical probe used in the assay. Increasing electron density is favorable to strong antioxidant activity in DPPH, and the phenol group is favored in ABTS, whereas electron deficient oxo-carotenoids are very potent in the superoxide radical assay. All oxo-carotenoids exhibited 105 similar to 151% better superoxide radical scavenging activity compared to beta-carotene (100%), whereas 38 similar to 155% in DPPH and 16 similar to 96% in ABTS radical scavenging activities were observed.
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关键词
antioxidant,apocarotenal,carotenoid,oxo-carotenoid,superoxide radical
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