Nanocomposite Based on a Natural Anionic Polysaccharide for Anticancer Drug Immobilization

Synthesis of polymer nanocomposite as nanocontainers for doxorubicin (DOX) is carried out at a molar ratio of monomer units of the anionic polysaccharide (sodium hyaluronate) and Ca2+-ions as a cross-linking agent equaled to 10/1. Highly water-soluble white fibrous products can be prepared. The hydrodynamic diameter of nanocompsite (Ca2+/Na-Hyaluronate) particles is equal to 150 nm. At the same time, diameter of the original sodium hyaluronate (Na-Hyaluronate) macromolecules is about 300 nm. The interaction between synthesized nanocomposite particles, Ca2+/Na-Hyaluronate, and DOX accompanied by a new complex formation can be confirmed by means of fluorimetry. Obtained results indicate that the nanocomposite is capable as an immobilizing doxorubicin nanocontainer.