Preparation of functional coating on magnesium alloy with hydrophilic polymers and bioactive peptides for improved corrosion resistance and biocompatibility

•A multifunctional coating was constructed on ZE21B alloy for biodegradable vascular stents.•MgF2 layer and hydrophilic polymers in the functional coating could effectively protect ZE21B alloy from overfast degradation.•Anticoagulant ACH11 peptides and ECs-selective REDV peptides in the functional coating could dramatically enhance the hemocompatibility and pro-endothelialization capacity of ZE21B alloy.•The functional coating systematically improved the corrosion resistance and biocompatibility of ZE21B alloy in vitro and in vivo.