Mechanochemical Ni‐Catalysed Arylation of ortho‐Hydroxyarylenaminones: Synthesis of Isoflavones
ADVANCED SYNTHESIS & CATALYSIS(2022)
Abstract
This work describes two new synthetic methods for the preparation of isoflavones following the Ni-catalysed domino arylation reactions of the vast range of ortho-hydroxyarylenaminones utilising aromatic bromides as well as carboxylic acids. The presented protocols tolerated significant variation of all coupling partners and enabled synthesis of isoflavone library of twenty-three representatives. This is the first communicated precedent where the mechanic energy was utilised in the synthesis of isoflavones following the domino cyclisation mode.
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Key words
Isoflavones,Arylation,Catalysis,Mechanochemistry,Methodology
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