Miconazole Promotes Cooperative Ability of a Mouse Model of Alzheimer Disease.

Ze Wang,Yanli Zhang,Weixi Feng,Yingting Pang,Sijia Chen,Shixin Ding,Yan Chen,Chengyu Sheng,Charles Marshall,Jingping Shi,Ming Xiao

The international journal of neuropsychopharmacology（2022）

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摘要

These results demonstrate that mPFC hypomyelination is involved in the cooperative deficits of APP/PS1 mice. Improving myelination through miconazole therapy may offer a potential therapeutic approach for early intervention in AD.

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关键词

Alzheimer disease,cooperative behavior,miconazole,myelin sheath,oligodendrocytes

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