Zhuanggu Zhitong Capsule alleviates postmenopausal osteoporosis in ovariectomized rats by regulating autophagy through AMPK/mTOR signaling pathway.

Zhitao Men, Chengjun Huang,Min Xu,Jiangtao Ma,Lei Wan,Jiachun Huang,Yanping Lin,Jiayao Yuan, Hong Huang,Hongxing Huang

Annals of translational medicine（2022）

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摘要

ZGZT affects autophagy by regulating AMPK/mTOR pathway, restores the homeostasis of bone metabolism and inhibits the release of inflammatory factors. Moreover, the regulation of feedback pathways between bone metabolism and inflammatory factors finally plays the role of "bone strengthening" and "pain relieving". ZGZT may be a new treatment for PMOP and relieving osteoporotic pain.

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关键词

Adenosine 5’-monophosphate-activated protein kinase (AMPK),autophagy,inflammatory factor,mammalian target of rapamycin (mTOR),postmenopausal osteoporosis (PMOP)

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