Advances in the study of HLA class Ib in maternal-fetal immune tolerance

Yiran Yang, Wanning Wang,Jing Weng, Huifang Li,Yanmin Ma,Lingyan Liu,Wei Ma

FRONTIERS IN IMMUNOLOGY(2022)

Cited 3|Views14
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Abstract
The HLA class Ib molecule is an alloantigen that causes transplant rejection on behalf of individual human and plays an important role in maternal-fetal immune tolerance. Early studies on HLA class Ib focused on the mechanism of HLA-G-induced immune escape, but in recent years, studies on the mechanism of HLA-G have deepened and gradually explored the mechanism of HLA-E and HLA-F, which are also HLA class Ib molecules. In the maternal-fetal interface, trophoblast cells express HLA class Ib molecules to protect the fetus from maternal immune cells by binding to inhibitory receptors of decidual immune cells (DICs) and shifting Th1/Th2 balance toward Th2 bias. Further studies on the molecular mechanism of HLA class Ib molecules provide a reference for its application in the field of clinical assisted reproduction.
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Key words
HLA class Ib, HLA-G, HLA-E, HLA-F, pregnancy, maternal-fetal immune tolerance, decidual immune cells
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