Dupilumab Use Is Associated With Protection From Coronavirus Disease 2019 Mortality: A Retrospective Analysis.

Alexandra N Donlan,Indika Mallawaarachchi,Jennifer M Sasson,Robert Preissner,Johanna J Loomba,William A Petri

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America（2023）

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摘要

We previously found that type 2 immunity promotes coronavirus disease 2019 (COVID-19) pathogenesis in a mouse model. To test relevance to human disease, we used electronic health record databases and determined that patients on dupilumab (anti-interleukin [IL]-4R monoclonal antibody that blocks IL-13 and IL-4 signaling) at the time of COVID-19 infection had lower mortality.

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COVID-19,dupilumab,infectious disease,type 2 immunity

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