Galectin-3 protects auditory function in female mice

Celia Zhang,Henry J Adler,Senthilvelan Manohar,Richard Salvi,Wei Sun,Mengxiao Ye,Bo Hua Hu

Hearing Research（2022）

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摘要

•Galectin-3 knockout causes progressive ABR threshold elevation in female C57BL/6 mice.•Galectin-3 knockout causes progressive DPOAE reduction in female C57BL/6 mice.•Galectin-3 knockout promotes progressive OHC loss in female C57BL/6 mice.•Galectin-3 has sex-specific effects on cochlear integrity through impaired OHC function.

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关键词

Galectin-3,Age-related hearing loss,Cochlea,Sex differences,Mice

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