Quantitative impact of pre‐analytical process on plasma uracil when testing for dihydropyrimidine dehydrogenase deficiency

Maud Maillard,Manon Launay,Bernard Royer,Jérôme Guitton,Elodie Gautier‐Veyret,Sophie Broutin,Camille Tron,Félicien Le Louedec,Joseph Ciccolini,Damien Richard,Hugo Alarcan,Vincent Haufroid,Naïma Tafzi,Antonin Schmitt,Marie‐Christine Etienne‐Grimaldi,Céline Narjoz,Fabienne Thomas

British Journal of Clinical Pharmacology（2022）

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摘要

Caution should be taken when interpreting U concentrations if the time before centrifugation exceeds 1 hour at RT, since it rises significantly afterwards. Not respecting the pre-analytical conditions for DPD phenotyping increases the risk of DPD status misclassification.

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关键词

dihydropyrimidine dehydrogenase,dihydrouracil,intra-individual variability,pre-analytical practices,uracil

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