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Intravenous Glu-plasminogen attenuates cholesterol crystal embolism-induced thrombotic angiopathy, acute kidney injury and kidney infarction.

Lyuben Lyubenov,Chongxu Shi,Danyang Zhao,Luying Yang,Yutian Lei,Elmina Mammadova-Bach,Letizia de Chiara,Roberto Semeraro,Samuela Landini,Paola Romagnani, Elena Vörg,Satish K Devarapu, Ricarda Welz, Stephan T Kiessig,Hans-Joachim Anders

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association（2023）

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Abstract
These results provide the first experimental evidence that Glu-Plg could be an innovative therapeutic strategy to attenuate thrombotic angiopathy, AKI, kidney necrosis and potentially other clinical manifestations of CC embolism syndrome.
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Key words
atheroembolism,fibrinolysis,renal failure,thrombotic microangiopathy
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