MET gene amplification is a mechanism of resistance to entrectinib in ROS1+ NSCLC.

Logan C Tyler,Anh T Le,Nan Chen,Hala Nijmeh,Liming Bao,Timothy R Wilson,David Chen,Brian Simmons,Kristen M Turner,Dean Perusse,Shailaja Kasibhatla,Jason Christiansen,Arkadiusz Z Dudek,Robert C Doebele

Thoracic cancer（2022）

引用 3|浏览15

暂无评分

摘要

Treatment with ROS1-selective inhibitors may lead to MET-mediated resistance. The discovery of ecDNA MET amplification is noteworthy, as ecDNA is associated with more aggressive cancers. Following progression on ROS1-selective inhibitors, MET gene testing and treatments targeting MET should be explored to overcome MET-driven resistance.

查看译文

关键词

MET,NSCLC,ROS1,drug resistance,entrectinib

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要