Genetic activation of glucokinase in a minority of pancreatic beta cells causes hypoglycemia in mice
Life Sciences(2022)
Abstract
Genetic activation of GK in a minority of β-cells is sufficient to change the glucose threshold for insulin secretion in the entire islet and thereby glucose homeostasis in the whole animal. These data support the model in which β-cells with higher GK activity function as 'hub' or 'trigger' cells and thus control insulin secretion by the β-cell collective within the islet.
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Key words
Islet,beta cell,Glucokinase,Hub cell,Trigger cell
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