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Itaconate Controls Its Own Synthesis Via Feedback-Inhibition of Reverse TCA Cycle Activity at IDH2.

Alexander Heinz,Yannic Nonnenmacher,Antonia Henne,Michelle-Amirah Khalil, Ketlin Bejkollari,Catherine Dostert,Shirin Hosseini,Oliver Goldmann,Wei He,Roberta Palorini,Charlene Verschueren,Martin Korte,Ferdinando Chiaradonna,Eva Medina,Dirk Brenner,Karsten Hiller

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease（2022）

Cited 13|Views44
Key words
Proinflammatory macrophage,TCA cycle,Reductive carboxylation,Mitochondrial metabolism,Redox balance,2-hydroxyglutarate
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