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Effects of durvalumab-metformin on head and neck squamous cell carcinoma (HNSCC) as revealed by digital spatial profiling (DSP)

J. Riordan,A. Linnenbach,A. Alnemri,R. Philips, S. Awosanya,S. Sussman,A. Luginbuhl,D. Cognetti,L. Harshyne,M. Mahoney,A. South,D. Whitaker-Menezes,M. Tuluc,A. Argiris,U. Martinez-Outschoorn,J. M. Johnson,J. M. Curry

Annals of Oncology（2022）

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Abstract
The combination therapy durvalumab (anti PD-L1) plus metformin (oral anti-hyperglycemic) targets multiple facets of the immunosuppressive tumor microenvironment (TME) in HNSCC to promote anti-tumor immunity. Characterization of the TME is crucial for understanding tumor-immune interactions underlying effective therapies.
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Key words
squamous cell carcinoma,digital spatial profiling,durvalumab-metformin
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