733MO γδT cells are effectors of immune checkpoint blockade in mismatch repair-deficient colon cancers with antigen presentation defects

J. Van De Haar,N.L. de Vries,V. Veninga,M. Chalabi,M. Ijsselsteijn,M. van der Ploeg,J. van den Bulk,D. Ruano, J.B.A.G. Haanen,T.N. Schumacher,L.F.A. Wessels,F. Koning,N.F.C.C. de Miranda,E.E. Voest

Annals of Oncology（2022）

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Abstract

DNA mismatch repair deficient (MMR-d) cancers present an abundance of neoantigens that likely underlies their exceptional responsiveness to immune checkpoint blockade (ICB). Early evidence has indicated that MMR-d cancers that evade CD8+ T cells through loss of Human Leukocyte Antigen (HLA) class I-mediated antigen presentation still respond to ICB, suggesting compensatory responsiveness of other immune effector cells in this context.

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Key words

733mo γδt cells,immune checkpoint blockade,antigen presentation defects,colon,repair-deficient

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