Photonic Crystal Enhanced Emission and Blinking Suppression for Single Quantum Dot Digital Resolution Biosensing of Cancer-associated miRNA Biomarkers

Yanyu Xiong,Qinglan Huang,Taylor D. Canady,Priyash Barya,Shengyan Liu,Opeyemi H. Arogundade,Caitlin M. Race,Xiaojing Wang,Lifeng Zhou,Xing Wang,Manish Kohli,Andrew M. Smith,Brian T. Cunningham

Conference on Lasers and Electro-Optics（2022）

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摘要

We report 3,000-fold signal enhancement with blinking suppression capability and single QD sensitivity using low-NA lens. Applied toward miRNA detection assays, we achieve single-base mutation selectivity, and 10-attomolar detection limit.

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关键词

miRNA detection,single-base mutation selectivity,photonic crystal enhanced emission,single quantum dot digital resolution biosensing,cancer-associated miRNA biomarkers,3 fold signal enhancement,000-fold signal enhancement,blinking suppression capability,single QD sensitivity,low-NA lens

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