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Benzoquinone and furopyridinone derivatives from the marine-derived fungus Talaromyces sp. MCCC 3A01752

Xuan Hong, Lingzhi Tang,Zhongwei Chen, Qiliang Lai,Beibei Zhang, Youwei Jiang, Xunjie Wang, Ruonan He,Jianhui Lin,Zongze Shao,Shan Lin,Weiyi Wang

NATURAL PRODUCT RESEARCH（2024）

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Abstract
Two new compounds, compounds 1 and 2, were obtained from the culture of a marine-derived fungus Talaromyces sp. MCCC 3A01752, together with 13 known compounds (3-15). Their structures were elucidated based on detailed analysis of NMR, HRESIMS, ECD spectra and OR value. Compound 1 exhibited antibacterial potential against Staphylococcus aureus with a MIC value of 100 mu M and cytotoxic activity against gastric cancer cell line MKN1 with a IC50 value of 78.0 mu M.
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Talaromyces,antimicrobial,cytotoxic,NMR
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