Chrome Extension
WeChat Mini Program
Use on ChatGLM

Targeting the key cholesterol biosynthesis enzyme squalene monooxygenasefor cancer therapy

FRONTIERS IN ONCOLOGY(2022)

Cited 2|Views7
No score
Abstract
Cholesterol metabolism is often dysregulated in cancer. Squalene monooxygenase (SQLE) is the second rate-limiting enzyme involved in cholesterol synthesis. Since the discovery of SQLE dysregulation in cancer, compelling evidence has indicated that SQLE plays a vital role in cancer initiation and progression and is a promising therapeutic target for cancer treatment. In this review, we provide an overview of the role and regulation of SQLE in cancer and summarize the updates of antitumor therapy targeting SQLE.
More
Translated text
Key words
cancer treatment, cell proliferation and migration, cholesterol metabolism, drug target, squalene epoxidase
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined