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Human duodenal submucosal glands contain a defined stem/progenitor subpopulation with liver-specific regenerative potential

Vincenzo Cardinale,Guido Carpino,Diletta Overi,Samira Safarikia,Wencheng Zhang,Matt Kanke,Antonio Franchitto,Daniele Costantini,Olga Riccioni,Lorenzo Nevi,Michele Chiappetta,Paolo Onori,Matteo Franchitto,Simone Bini,Yu-Han Hung,Quirino Lai,Ilaria Zizzari,Marianna Nuti,Carmine Nicoletti,Saula Checquolo,Laura Di Magno,Maria Valeria Giuli,Massimo Rossi,Praveen Sethupathy,Lola M Reid,Domenico Alvaro,Eugenio Gaudio

Journal of Hepatology（2023）

Cited 6|Views68
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Abstract
•Endodermal progenitors are present in the submucosal glands of adult human duodenum.•Duodenal submucosal gland cells can be isolated from adult human duodenum.•Duodenal submucosal gland cells can acquire hepatocyte functional traits in vitro.•Duodenal submucosal gland cells rescue liver damage in murine chronic liver injury.
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Key words
Stem cells,Endoderm,Duodenum,Regeneration,Liver,Cell therapy
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