Hepatocyte leukotriene B4 receptor 1 promotes NAFLD development in obesity.

Xingfeng Liu,Kai Wang,Luhai Wang,Lijuan Kong,Shaocong Hou,Yanjun Wan,Chunxiao Ma,Jingwen Chen,Xiaowei Xing,Caiyi Xing,Qian Jiang,Qijin Zhao,Bing Cui,Zhifeng Huang,Pingping Li

Hepatology (Baltimore, Md.)（2022）

引用 8|浏览27

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摘要

LTB4/Ltb4r1 promotes hepatocyte lipogenesis directly by activating PKA-IRE1α-XBP1s to promote lipogenic gene expression. Inhibition of hepatocyte Ltb4r1 improved hepatic steatosis and insulin resistance. Ltb4r1 is a potential therapeutic target for NAFLD.

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