Nonpeptide GPIIB/IIIA inhibitors. 16. Thieno[2,3-b]thiophene α-sulfonamides are potent inhibitors of platelet aggregation

John D. Prugh,Robert J. Gould,Robert J. Lynch,Guixiang Zhang,Jacquelynn J. Cook,Marie A. Holahan,Maria T. Stranieri,Gary R. Sitko, S. Lee Gaul,Rodney A. Bednar,Bohumil Bednar,George D. Hartman

Bioorganic & Medicinal Chemistry Letters（1997）

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摘要

Centrally constrained thieno[2,3-b]thiophene sulfonamides have provided a potent, selective, orally active series of platelet aggregation inhibitors. Compound 21 showed excellent activity in the dog after a single oral dose of 200 μg/kg.

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