Hypoxia-Inducible Factor 1 Activation From Adipose Protein 2-Cre Mediated Knockout Of Von Hippel-Lindau Gene Leads To Embryonic Lethality
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY（2012）
Abstract
1. von Hippel-Lindau protein, an E3 ubiquitin ligase from the von Hippel-Lindau (Vhl) gene, inhibits the transcriptional activity of hypoxia-inducible factor 1a in cells. To gain insight into the hypoxia-inducible factor 1a signalling pathway in adipose tissue, a study was conducted to generate fat-specific Vhl knockout mice.
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Key words
adipose tissue,aP2-Cre,haemorrhage,hypoxia,hypoxia-inducible factor-1,von Hippel-Lindau
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