Carfilzomib induced microangiopathy due to accumulation with Paxlovid.

Thrombotic microangiopathy (TMA) syndromes are characterized by the association of hemolytic microangiopathic anemia, thrombocytopenia, and organ injury due to arteriolar and capillary thrombosis. Establishing an etiological diagnosis of TMA is essential because it can help identify which therapies will be beneficial. In adults, etiologies of TMA include shiga toxin-related hemolytic uremic syndrome, ADAMTS13 (genetic or acquired) deficiency (thrombotic thrombocytopenic purpura) and atypical hemolytic uremic syndrome secondary to complement alternative pathway dysregulation.