MlaC belongs to a unique class of non-canonical substrate-binding proteins and follows a novel phospholipid-binding mechanism

Journal of Structural Biology（2022）

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摘要

•MlaC comprises two domains viz. NTF2-like and PBP.•Each domain can be divided into two subdomains that are arranged in discontinuous fashion.•MlaC follows a unique “segmented domain movement’’ mechanism.•MlaC has a unique evolutionary ancestry which is different from canonical SBPs.

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关键词

ABC transporter,Periplasmic protein,Membrane lipid asymmetry,Segmented domain movement,Mla transport system

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