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Neurodegeneration by α-synuclein-specific T cells in AAV-A53T-α-synuclein Parkinson’s disease mice

Akua A. Karikari,Rhonda L. McFleder,Eliana Ribechini,Robert Blum,Valentin Bruttel,Susanne Knorr,Mona Gehmeyr,Jens Volkmann,Jonathan M. Brotchie,Fadhil Ahsan,Beatrice Haack,Camelia-Maria Monoranu,Ursula Keber, Rima Yeghiazaryan,Axel Pagenstecher,Tobias Heckel,Thorsten Bischler,Jörg Wischhusen,James B. Koprich,Manfred B. Lutz

Brain, Behavior, and Immunity（2022）

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Abstract
•RNA-sequencing of immune cells from PD mouse brains confirm a pro-inflammatory gene profile.•T cells mediate dopaminergic neurodegeneration in AAV-A53T-α-synuclein PD mice.•T cell responses are directed against A53T-α-synuclein peptides.
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Key words
PD,SN,TNF,IL,MPTP,6-OHDA,AAV1/2,haSyn,EV,GO,RAG-1,BM,DAT,HVA,DA,IFN,DOPAC,CTCF
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