Neurodegeneration by α-synuclein-specific T cells in AAV-A53T-α-synuclein Parkinson’s disease mice
Brain, Behavior, and Immunity(2022)
Abstract
•RNA-sequencing of immune cells from PD mouse brains confirm a pro-inflammatory gene profile.•T cells mediate dopaminergic neurodegeneration in AAV-A53T-α-synuclein PD mice.•T cell responses are directed against A53T-α-synuclein peptides.
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Key words
PD,SN,TNF,IL,MPTP,6-OHDA,AAV1/2,haSyn,EV,GO,RAG-1,BM,DAT,HVA,DA,IFN,DOPAC,CTCF
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