Berberine exerts neuroprotective activities against cerebral ischemia/reperfusion injury through up-regulating PPAR-γ to suppress NF-κB-mediated pyroptosis
Brain Research Bulletin（2021）
Abstract
•OGD induces neuron pyroptosis.•BBR inhibits neuronal pyroptosis.•OGD induces up-regulation of PPAR-γ expression.•BBR regulates PPAR-γ expression.•BBR suppresses NF-κB-mediated pyroptosis by up-regulating PPAR-γ.
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Key words
Berberine,PPAR-γ,Cerebral ischemia/reperfusion injury,NF-κB,Pyroptosis
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